Reaction Details | |||
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Target | Neutrophil elastase | ||
Ligand | BDBM211908 | ||
Substrate/Competitor | BDBM211682 | ||
Meas. Tech. | Neutrophil Elastase Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <1±n/a nM | ||
Comments | extracted | ||
Citation | Gnamm, C; Oost, T; Peters, S; Hoesch, H; Ries, UJ Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent US9290459 Publication Date 3/22/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Neutrophil elastase | |||
Name: | Neutrophil elastase | ||
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | ||
Type: | Enzyme | ||
Mol. Mass.: | 28532.38 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08246 | ||
Residue: | 267 | ||
Sequence: |
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BDBM211908 | |||
BDBM211682 | |||
Name | BDBM211908 | ||
Synonyms: | US9290459, 48.2 | US9670166, 48.2 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H23F3N4O5S | ||
Mol. Mass. | 584.566 | ||
SMILES | CS(=O)(=O)c1cc(ccc1[C@H]1N(C(=O)NC2C3CC2C3)C(=O)N(C2=C1C(=O)CC2)c1cccc(c1)C(F)(F)F)C#N |r,wU:10.10,c:26,(-.3,4.09,;-1.64,3.32,;-2.41,1.99,;-.87,1.99,;-2.97,4.09,;-2.97,5.63,;-4.3,6.4,;-5.64,5.63,;-5.64,4.09,;-4.3,3.32,;-4.3,-.38,;-2.97,-1.15,;-1.64,-.38,;-1.64,1.15,;-.3,-1.15,;1.03,-.38,;2.52,-.78,;2.52,.76,;1.43,1.1,;2.97,1.1,;-2.97,-2.69,;-1.64,-3.46,;-4.3,-3.46,;-5.64,-2.69,;-5.64,-1.15,;-7.1,-.68,;-7.87,.65,;-8.01,-1.92,;-7.1,-3.17,;-4.3,-5,;-5.64,-5.77,;-5.64,-7.31,;-4.3,-8.08,;-2.92,-7.34,;-2.97,-5.77,;-1.59,-8.11,;-.25,-8.88,;-2.36,-9.45,;-.82,-6.78,;-4.3,7.94,;-4.3,9.48,)| | ||
Structure |