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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nicotinamide phosphoribosyltransferase | ||
| Ligand | BDBM217311 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay | ||
| pH | 7.5±n/a | ||
| IC50 | 0.86±n/a nM | ||
| Comments | extracted | ||
| Citation |  Curtin, ML; Sorensen, BK; Heyman, HR; Clark, RF; Woller, KR; Shah, OJ; Michaelides, M; Tse, C; Vasudevan, A; Mack, H; Hansen, TM; Sweis, R; Pliushchev, MA NAMPT and rock inhibitors US Patent US9302989 Publication Date 4/5/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nicotinamide phosphoribosyltransferase | |||
| Name: | Nicotinamide phosphoribosyltransferase | ||
| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55524.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43490 | ||
| Residue: | 491 | ||
| Sequence: |
| ||
| BDBM217311 | |||
| n/a | |||
| Name | BDBM217311 | ||
| Synonyms: | US9302989, 1552 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H30N4O2 | ||
| Mol. Mass. | 418.5313 | ||
| SMILES | O=C(CC1CC1)N[C@H]1CC[C@H](CC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 |wU:7.7,10.14,(-5.33,2.9,;-6.1,1.56,;-7.64,1.56,;-8.41,2.9,;-9.75,3.67,;-8.41,4.44,;-5.33,.23,;-3.79,.23,;-3.02,1.56,;-1.48,1.56,;-.71,.23,;-1.48,-1.11,;-3.02,-1.11,;.83,.23,;1.6,-1.11,;3.14,-1.11,;3.91,.23,;5.45,.23,;6.22,1.56,;5.45,2.9,;7.76,1.56,;8.66,2.81,;10.13,2.33,;11.46,3.1,;12.79,2.33,;12.79,.79,;11.46,.02,;10.13,.79,;8.66,.32,;3.14,1.56,;1.6,1.56,)| | ||
| Structure | 
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