Reaction Details |
| Report a problem with these data |
Target | Bromodomain-containing protein 4 [352-457] |
---|
Ligand | BDBM220434 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Bromodomain Domain Binding Assay |
---|
pH | 6±n/a |
---|
Temperature | 298.15±n/a K |
---|
Ki | 0.75±n/a nM |
---|
Comments | extracted |
---|
Citation | Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bromodomain-containing protein 4 [352-457] |
---|
Name: | Bromodomain-containing protein 4 [352-457] |
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 12432.37 |
Organism: | Homo sapiens (Human) |
Description: | BDII: amino acid E352-M457 |
Residue: | 106 |
Sequence: | EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE
YRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
|
|
|
BDBM220434 |
---|
n/a |
---|
Name | BDBM220434 |
Synonyms: | US9296741, 23 |
Type | Small organic molecule |
Emp. Form. | C20H18N4O4S |
Mol. Mass. | 410.446 |
SMILES | Cn1cc(-c2cc(NS(C)(=O)=O)cnc2Oc2ccccc2)c2cc[nH]c2c1=O |
Structure |
|