| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
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| Ligand | BDBM222493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radiometric Filter-Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 4.9±n/a nM |
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| Comments | extracted |
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| Citation |  Furet, P; Grotzfeld, RM; Jahnke, W; Jones, DB; Manley, PW; Marzinzik, A; Moussaoui, S; Pelle, XF; Salem, B; Schoepfer, J Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9315489 Publication Date 4/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [64-515] |
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| Name: | Tyrosine-protein kinase ABL1 [64-515] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51539.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 64-515 |
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| Residue: | 452 |
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| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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| BDBM222493 |
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| n/a |
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| Name | BDBM222493 |
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| Synonyms: | US9315489, 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11ClF3N3O2 |
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| Mol. Mass. | 381.736 |
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| SMILES | FC(F)(F)Oc1ccc(NC(=O)c2ccc(Cl)c(c2)-c2cc[nH]n2)cc1 |
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| Structure | 
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