| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM192298 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CETP Inhibition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 22.9±n/a nM |
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| Comments | extracted |
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| Citation |  Kawai, Y; Iwase, N; Kikuchi, O; Takata, K; Motoyama, T; Hagihara, M Acid addition salt of substituted pyridine compound US Patent US9321747 Publication Date 4/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM192298 |
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| n/a |
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| Name | BDBM192298 |
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| Synonyms: | US9187450, 45 | US9321747, 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H46F6N4O4S |
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| Mol. Mass. | 768.852 |
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| SMILES | CC1(C)C[C@H](O)c2c(C1)nc(C1CCN(CC1)c1ncc(OCCCS(C)(=O)=O)cn1)c([C@@H](F)c1ccc(cc1)C(F)(F)F)c2C1CCC(F)(F)CC1 |r| |
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| Structure | 
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