| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM50240374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caspase Catalytic Activity Assay |
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| pH | 7.4±n/a |
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| IC50 | 4.4e+3± 2e+2 nM |
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| Comments | extracted |
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| Citation |  Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol24:281-292 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
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| Type: | Enzyme |
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| Mol. Mass.: | 45154.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29466 |
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| Residue: | 404 |
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| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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| BDBM50240374 |
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| n/a |
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| Name | BDBM50240374 |
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| Synonyms: | 3-(4-biphenylylcarbonyl)propionic acid | 3-(4-phenylbenzoyl)propionic acid | 4-(4-biphenylyl)-4-oxobutyric acid | 4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 4-biphenyl-4-yl-4-oxobutanoic acid | CHEMBL277522 | Fenbufen | gamma-oxo(1,1'-biphenyl)-4-butanoic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14O3 |
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| Mol. Mass. | 254.2806 |
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| SMILES | OC(=O)CCC(=O)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
|
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