Reaction Details | |||
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Target | Lysophosphatidic acid receptor 1 | ||
Ligand | BDBM50398089 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 58±n/a nM | ||
Comments | extracted | ||
Citation | Gabriel, SD; Hamilton, MM; Lucas, MC; Qian, Y; Sidduri, A N-alkyltriazole compounds as LPAR antagonists US Patent US9321738 Publication Date 4/26/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysophosphatidic acid receptor 1 | |||
Name: | Lysophosphatidic acid receptor 1 | ||
Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 41120.55 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q92633 | ||
Residue: | 364 | ||
Sequence: |
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BDBM50398089 | |||
n/a | |||
Name | BDBM50398089 | ||
Synonyms: | CHEMBL2182051 | US9321738, 14 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H30N4O4 | ||
Mol. Mass. | 462.5408 | ||
SMILES | C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(cc1)C1CCC(CC(O)=O)CC1)c1ccccc1 |r,wD:1.0,(51.8,-50.88,;51.04,-52.22,;49.5,-52.23,;48.72,-50.9,;49.48,-49.56,;47.18,-50.91,;46.4,-49.58,;44.94,-49.14,;44.9,-47.61,;46.34,-47.1,;47.28,-48.32,;48.82,-48.29,;43.57,-49.86,;43.51,-51.4,;42.15,-52.11,;40.85,-51.28,;40.92,-49.74,;42.28,-49.03,;39.48,-51.99,;39.42,-53.53,;38.05,-54.24,;36.75,-53.41,;35.38,-54.12,;34.08,-53.29,;32.71,-54,;34.15,-51.75,;36.82,-51.86,;38.19,-51.16,;51.82,-53.55,;51.06,-54.88,;51.83,-56.21,;53.38,-56.2,;54.14,-54.85,;53.35,-53.52,)| | ||
Structure |