| Reaction Details |
|---|
 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Ligand | BDBM227590 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDK Inhibition Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 298.15±0 K |
|---|
| IC50 | 6.78e+3±n/a nM |
|---|
| Citation |  Tso, SC; Qi, X; Gui, WJ; Wu, CY; Chuang, JL; Wernstedt-Asterholm, I; Morlock, LK; Owens, KR; Scherer, PE; Williams, NS; Tambar, UK; Wynn, RM; Chuang, DT Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket. J Biol Chem289:4432-43 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46153.78 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15119 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
|
|
|
|---|
| BDBM227590 |
|---|
| n/a |
|---|
| Name | BDBM227590 |
|---|
| Synonyms: | PA1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12BrNO3 |
|---|
| Mol. Mass. | 334.165 |
|---|
| SMILES | Oc1cc(O)c(cc1Br)C(=O)N1Cc2ccccc2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
