| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein HSP 90-alpha [1-236] |
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| Ligand | BDBM227589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Isothermal Titration Calorimetry (ITC) |
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| pH | 7.5±0 |
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| Temperature | 288.15±0 K |
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| Kd | 46.3±7.2 nM |
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| Citation |  Tso, SC; Qi, X; Gui, WJ; Wu, CY; Chuang, JL; Wernstedt-Asterholm, I; Morlock, LK; Owens, KR; Scherer, PE; Williams, NS; Tambar, UK; Wynn, RM; Chuang, DT Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket. J Biol Chem289:4432-43 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock protein HSP 90-alpha [1-236] |
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| Name: | Heat shock protein HSP 90-alpha [1-236] |
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| Synonyms: | HS90A_HUMAN | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat-shock protein 90 (Hsp90) |
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| Type: | Enzyme |
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| Mol. Mass.: | 26556.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Hsp90 (1-236 aa) |
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| Residue: | 236 |
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| Sequence: | MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE
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| BDBM227589 |
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| n/a |
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| Name | BDBM227589 |
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| Synonyms: | Radicicol |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClO6 |
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| Mol. Mass. | 364.777 |
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| SMILES | C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |r,c:7,t:9| |
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| Structure | 
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