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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM229416 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF Biochemical Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brubaker, J; Childers, ML; Christopher, M; Close, JT; Katz, JD; Jung, J; Peterson, S; Siliphaivanh, P; Siu, T; Smith, GF; Torres, LE; Woo, HC; Young, JR; Zhang, H Cyanomethylpyrazole carboxamides as janus kinase inhibitors US Patent US9328099 Publication Date 5/3/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM229416 | |||
| n/a | |||
| Name | BDBM229416 | ||
| Synonyms: | US9328099, 40-31 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28F4N6O3S | ||
| Mol. Mass. | 556.576 | ||
| SMILES | NC(=O)c1cn(nc1Nc1ccc(cc1)S(=O)(=O)C(F)F)C1(CC#N)CCC(CC1)N1CCC(F)(F)CC1 |(.62,5.31,;-.47,4.22,;-1.96,4.62,;-.07,2.73,;-.98,1.49,;-.07,.24,;1.39,.72,;1.39,2.26,;2.73,3.03,;4.06,2.26,;4.06,.72,;5.39,-.05,;6.73,.72,;6.73,2.26,;5.39,3.03,;8.06,-.05,;9.4,.72,;9.4,-.82,;8.06,-1.59,;9.4,-2.36,;6.73,-2.36,;-.47,-1.25,;.62,-2.33,;.22,-3.82,;-.18,-5.31,;-1.56,-.16,;-3.05,-.56,;-3.45,-2.04,;-2.36,-3.13,;-.87,-2.73,;-4.93,-2.44,;-6.02,-1.35,;-7.51,-1.75,;-7.91,-3.24,;-9.4,-2.84,;-9,-4.33,;-6.82,-4.33,;-5.33,-3.93,)| | ||
| Structure | 
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