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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM229434 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF Biochemical Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 3±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brubaker, J; Childers, ML; Christopher, M; Close, JT; Katz, JD; Jung, J; Peterson, S; Siliphaivanh, P; Siu, T; Smith, GF; Torres, LE; Woo, HC; Young, JR; Zhang, H Cyanomethylpyrazole carboxamides as janus kinase inhibitors US Patent US9328099 Publication Date 5/3/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM229434 | |||
| n/a | |||
| Name | BDBM229434 | ||
| Synonyms: | US9328099, 40-59 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H26F2N6O4S | ||
| Mol. Mass. | 544.574 | ||
| SMILES | NC(=O)c1cn(nc1Nc1ccc(cc1)S(=O)(=O)C(F)F)C1(CC#N)CCC(CC1)Nc1ccc(O)cc1 |(4.42,-5.21,;5.19,-3.88,;6.73,-3.88,;4.42,-2.55,;4.9,-1.08,;3.65,-.18,;2.41,-1.08,;2.88,-2.55,;1.79,-3.64,;.31,-3.24,;-.09,-1.75,;-1.58,-1.35,;-2.67,-2.44,;-2.27,-3.93,;-.78,-4.33,;-4.16,-2.04,;-3.84,-.53,;-4.63,-3.51,;-5.62,-1.57,;-6.77,-2.6,;-6.1,-.1,;3.65,1.36,;4.99,2.13,;4.99,3.67,;4.99,5.21,;2.32,.59,;.99,1.36,;.99,2.9,;2.32,3.67,;3.65,2.9,;-.35,3.67,;-1.68,2.9,;-3.02,3.67,;-4.35,2.9,;-4.35,1.36,;-5.68,.59,;-3.02,.59,;-1.68,1.36,)| | ||
| Structure | 
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