| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor alpha |
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| Ligand | BDBM86689 |
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| Substrate/Competitor | n/a |
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| Ki | 1250±n/a nM |
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| Citation |  Jacobson, PB; von Geldern, TW; Ohman, L; Osterland, M; Wang, J; Zinker, B; Wilcox, D; Nguyen, PT; Mika, A; Fung, S; Fey, T; Goos-Nilsson, A; Grynfarb, M; Barkhem, T; Marsh, K; Beno, DW; Nga-Nguyen, B; Kym, PR; Link, JT; Tu, N; Edgerton, DS; Cherrington, A; Efendic, S; Lane, BC; Opgenorth, TJ Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J Pharmacol Exp Ther314:191-200 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Thyroid hormone receptor alpha |
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| Name: | Thyroid hormone receptor alpha |
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| Synonyms: | C-erba-alpha | Nr1a1 | THA_RAT | Thra | Thyroid hormone receptor alpha | thyroid alpha |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55077.31 |
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| Organism: | RAT |
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| Description: | thyroid alpha 0 RAT::P63059 |
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| Residue: | 492 |
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| Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCPLKSSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHVATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQF
GEAGSLRGPVLQHQSPKSPQQRLLELLHRSGILHSRAVCGEDDSSEASSLSSSSSDEDTE
VFEDLAGKAASP
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| BDBM86689 |
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| n/a |
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| Name | BDBM86689 |
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| Synonyms: | CAS_84371-65-3 | NSC_55245 | RU-486 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35NO2 |
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| Mol. Mass. | 429.5937 |
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| SMILES | CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)c1ccc(cc1)N(C)C |c:18,t:11| |
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| Structure | 
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