| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1A |
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| Ligand | BDBM143566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALK1-6 enzymatic assays |
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| pH | 7.5±n/a |
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| IC50 | 29±n/a nM |
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| Comments | extracted |
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| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1A |
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| Name: | Bone morphogenetic protein receptor type-1A |
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| Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60204.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36894 |
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| Residue: | 532 |
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| Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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| BDBM143566 |
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| n/a |
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| Name | BDBM143566 |
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| Synonyms: | US10017516, Compound 13 | US9682983, 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N5 |
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| Mol. Mass. | 419.5209 |
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| SMILES | Cc1cc(-c2cnn3cc(cnc23)-c2ccc(cc2)C2CCNCC2)c2ccccc2n1 |
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| Structure | 
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