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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM230098 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.48±n/a nM | ||
| Comments | extracted | ||
| Citation |  Batt, DG; Bertrand, MB; Delucca, G; Galella, MA; Ko, SS; Langevine, CM; Liu, Q; Shi, Q; Srivastava, AS; Tino, JA; Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent US9334290 Publication Date 5/10/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
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| BDBM230098 | |||
| n/a | |||
| Name | BDBM230098 | ||
| Synonyms: | US9334290, 21 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H24F2N4O4 | ||
| Mol. Mass. | 554.5435 | ||
| SMILES | Cc1c(cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.75,9.88,;1.42,9.11,;.08,9.88,;-1.25,9.11,;-1.25,7.57,;.08,6.8,;1.42,7.57,;2.75,6.8,;2.75,5.26,;1.42,4.49,;4.09,4.49,;5.42,5.26,;6.75,4.49,;6.75,2.95,;8.09,5.26,;8.09,6.8,;6.75,7.57,;5.42,6.8,;4.09,7.57,;4.09,9.11,;.08,11.42,;1.42,12.19,;2.75,11.42,;1.42,13.73,;.08,14.5,;.08,16.04,;1.42,16.81,;-1.25,16.81,;-1.25,13.73,;-2.71,14.2,;-3.62,12.96,;-5.15,12.8,;-5.78,11.39,;-4.87,10.14,;-3.34,10.31,;-2.71,11.71,;-1.25,12.19,;-7.32,11.39,;-8.09,10.06,;-6.55,10.06,;-8.09,12.72,)| | ||
| Structure | 
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