| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylalanine--tRNA ligase alpha/beta subunit |
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| Ligand | BDBM231666 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aminoacylation Assay |
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| pH | 8±n/a |
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| IC50 | 2.2±n/a nM |
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| Comments | extracted |
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| Citation |  Abibi, A; Ferguson, AD; Fleming, PR; Gao, N; Hajec, LI; Hu, J; Laganas, VA; McKinney, DC; McLeod, SM; Prince, DB; Shapiro, AB; Buurman, ET The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. J Biol Chem289:21651-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylalanine--tRNA ligase alpha/beta subunit |
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| Name: | Phenylalanine--tRNA ligase alpha/beta subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase (PheRS) |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | E. coli PheRS |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Phenylalanine--tRNA ligase alpha subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase alpha subunit (PheRS) | SYFA_ECOLI | pheS |
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| Type: | Enzyme |
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| Mol. Mass.: | 36828.85 |
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| Organism: | Escherichia coli (Enterobacteria) |
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| Description: | P08312 |
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| Residue: | 327 |
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| Sequence: | MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVI
NEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFF
GELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKA
QQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQ
IRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGME
RLTMLRYGVTDLRSFFENDLRFLKQFK
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| Component 2 |
| Name: | Phenylalanine--tRNA ligase beta subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase beta subunit (PheRSβ) | SYFB_ECOLI | pheT |
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| Type: | Enzyme |
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| Mol. Mass.: | 87356.43 |
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| Organism: | Escherichia coli (Enterobacteria) |
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| Description: | P07395 |
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| Residue: | 795 |
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| Sequence: | MKFSELWLREWVNPAIDSDALANQITMAGLEVDGVEPVAGSFHGVVVGEVVECAQHPNAD
KLRVTKVNVGGDRLLDIVCGAPNCRQGLRVAVATIGAVLPGDFKIKAAKLRGEPSEGMLC
SFSELGISDDHSGIIELPADAPIGTDIREYLKLDDNTIEISVTPNRADCLGIIGVARDVA
VLNQLPLVQPEIVPVGATIDDTLPITVEAPEACPRYLGRVVKGINVKAPTPLWMKEKLRR
CGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNAD
TLVIADHNKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRY
ERGVDPALQHKAMERATRLLIDICGGEAGPVIDITNEATLPKRATITLRRSKLDRLIGHH
IADEQVTDILRRLGCEVTEGKDEWQAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPVQ
ASLIMGTHREADLSLKRVKTLLNDKGYQEVITYSFVDPKVQQMIHPGVEALLLPSPISVE
MSAMRLSLWTGLLATVVYNQNRQQNRVRIFESGLRFVPDTQAPLGIRQDLMLAGVICGNR
YEEHWNLAKETVDFYDLKGDLESVLDLTGKLNEVEFRAEANPALHPGQSAAIYLKGERIG
FVGVVHPELERKLDLNGRTLVFELEWNKLADRVVPQAREISRFPANRRDIAVVVAENVPA
ADILSECKKVGVNQVVGVNLFDVYRGKGVAEGYKSLAISLILQDTSRTLEEEEIAATVAK
CVEALKERFQASLRD
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| BDBM231666 |
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| n/a |
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| Name | BDBM231666 |
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| Synonyms: | N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido)benzenesulfonamide (1b) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3S2 |
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| Mol. Mass. | 441.527 |
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| SMILES | O=C(Nc1nccs1)Nc1cccc(c1)S(=O)(=O)NCCc1c[nH]c2ccccc12 |
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| Structure | 
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