Reaction Details |
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Target | Phenylalanine--tRNA ligase alpha/beta subunit |
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Ligand | BDBM231668 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Aminoacylation Assay |
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pH | 8±n/a |
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IC50 | 5.6e+2±n/a nM |
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Comments | extracted |
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Citation | Abibi, A; Ferguson, AD; Fleming, PR; Gao, N; Hajec, LI; Hu, J; Laganas, VA; McKinney, DC; McLeod, SM; Prince, DB; Shapiro, AB; Buurman, ET The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. J Biol Chem289:21651-62 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phenylalanine--tRNA ligase alpha/beta subunit |
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Name: | Phenylalanine--tRNA ligase alpha/beta subunit |
Synonyms: | Phenylalanyl-tRNA synthetase (PheRS) |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | E. coli PheRS |
Components: | This complex has 2 components. |
Component 1 |
Name: | Phenylalanine--tRNA ligase alpha subunit |
Synonyms: | Phenylalanyl-tRNA synthetase alpha subunit (PheRS) | SYFA_ECOLI | pheS |
Type: | Enzyme |
Mol. Mass.: | 36828.85 |
Organism: | Escherichia coli (Enterobacteria) |
Description: | P08312 |
Residue: | 327 |
Sequence: | MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVI
NEAKEQVQQALNARKAELESAALNARLAAETIDVSLPGRRIENGGLHPVTRTIDRIESFF
GELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKA
QQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQ
IRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGME
RLTMLRYGVTDLRSFFENDLRFLKQFK
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Component 2 |
Name: | Phenylalanine--tRNA ligase beta subunit |
Synonyms: | Phenylalanyl-tRNA synthetase beta subunit (PheRSβ) | SYFB_ECOLI | pheT |
Type: | Enzyme |
Mol. Mass.: | 87356.43 |
Organism: | Escherichia coli (Enterobacteria) |
Description: | P07395 |
Residue: | 795 |
Sequence: | MKFSELWLREWVNPAIDSDALANQITMAGLEVDGVEPVAGSFHGVVVGEVVECAQHPNAD
KLRVTKVNVGGDRLLDIVCGAPNCRQGLRVAVATIGAVLPGDFKIKAAKLRGEPSEGMLC
SFSELGISDDHSGIIELPADAPIGTDIREYLKLDDNTIEISVTPNRADCLGIIGVARDVA
VLNQLPLVQPEIVPVGATIDDTLPITVEAPEACPRYLGRVVKGINVKAPTPLWMKEKLRR
CGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNAD
TLVIADHNKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRY
ERGVDPALQHKAMERATRLLIDICGGEAGPVIDITNEATLPKRATITLRRSKLDRLIGHH
IADEQVTDILRRLGCEVTEGKDEWQAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPVQ
ASLIMGTHREADLSLKRVKTLLNDKGYQEVITYSFVDPKVQQMIHPGVEALLLPSPISVE
MSAMRLSLWTGLLATVVYNQNRQQNRVRIFESGLRFVPDTQAPLGIRQDLMLAGVICGNR
YEEHWNLAKETVDFYDLKGDLESVLDLTGKLNEVEFRAEANPALHPGQSAAIYLKGERIG
FVGVVHPELERKLDLNGRTLVFELEWNKLADRVVPQAREISRFPANRRDIAVVVAENVPA
ADILSECKKVGVNQVVGVNLFDVYRGKGVAEGYKSLAISLILQDTSRTLEEEEIAATVAK
CVEALKERFQASLRD
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BDBM231668 |
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n/a |
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Name | BDBM231668 |
Synonyms: | 2-(3-(4-Cyanopyridin-2-ylamino)phenoxy)-N-methylacetamide (2b) |
Type | Small organic molecule |
Emp. Form. | C15H14N4O2 |
Mol. Mass. | 282.2973 |
SMILES | CNC(=O)COc1cccc(Nc2cc(ccn2)C#N)c1 |
Structure |
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