| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylalanine--tRNA ligase alpha/beta subunit |
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| Ligand | BDBM231665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aminoacylation Assay |
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| pH | 8±n/a |
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| IC50 | 22±n/a nM |
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| Comments | extracted |
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| Citation |  Abibi, A; Ferguson, AD; Fleming, PR; Gao, N; Hajec, LI; Hu, J; Laganas, VA; McKinney, DC; McLeod, SM; Prince, DB; Shapiro, AB; Buurman, ET The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. J Biol Chem289:21651-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylalanine--tRNA ligase alpha/beta subunit |
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| Name: | Phenylalanine--tRNA ligase alpha/beta subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase (PheRS) |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | P. aeruginosa PheRS |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Phenylalanine--tRNA ligase alpha subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase alpha subunit (PheRSα) |
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| Type: | Enzyme |
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| Mol. Mass.: | 38058.59 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | Q9I0A3 |
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| Residue: | 338 |
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| Sequence: | MENLDALVSQALEAVRHTEDVNALEQIRVHYLGKKGELTQVMKTLGDLPAEERPKVGALI
NVAKEKVQDVLNARKTELEGAALAARLAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCF
SRIGYEVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMES
QQPPIRIVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQLE
VRFRPSFFPFTEPSAEVDIQCVICSGNGCRVCKQTGWLEVMGCGMVHPNVLRMSNIDPEK
FQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR
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| Component 2 |
| Name: | Phenylalanine--tRNA ligase beta subunit |
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| Synonyms: | Phenylalanyl-tRNA synthetase beta subunit (PheRSβ) | SYFB_PSEAE | pheT |
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| Type: | Enzyme |
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| Mol. Mass.: | 86782.17 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | Q9I0A4 |
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| Residue: | 792 |
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| Sequence: | MKFSEKWLRSWANPQVSHDELVARLSMVGLEVDADLPVAGAFSGVVVGEVLSTEQHPDAD
KLRVCQVSNGSETFQVVCGAPNVRAGLKIPFAMIGAELPDDFKIKKAKLRGVESFGMLCS
AKELQISEENAGLLELPADAPVGQDVRTYLELADYTIEVGLTPNRGDCLSLAGLAREVSA
IYDVPLAPVAVDAVAAQHDETRPVELAAPAACPRYLGRVIRNVDLSRPTPLWMVERLRRS
DIRSIDPVVDVTNYVMIELGQPMHAFDLAEINGGVRVRMAEDGEKLVLLDGQEITLRADT
LVIADHQRALAIAGVMGGEHSGVSDSTRDLFLEAAFFDTIALAGKARSYGLHTDSSHRFE
RGVDSQLARKAMERATRLILDIVGGEPGPIVEQVSEAHLPKVAPITLRAERVTQMLGMPL
DAAEIVRLLQALELTVVADGEGQWSVGVPSHRFDISLEVDLIEELARLYGYNRLPVRYPQ
ARLAPNNKPEARAALPLLRRLLVARGYQEAITFSFIDPALFELFDPGTQPLTLANPISAD
MAAMRSSLWPGLVKALQHNLNRQQSRVRLFESGLRFVGQLEGLKQEAMLAGAICGKRLPE
GWANGRDGVDFFDAKADVEAVLASAGALGDFSFVPGEHPALHPGQTARIEREGRLVGYLG
ALHPELAKKLDLEQPVFLFELLLAEVVDGHLPKFRELSRFPEVRRDLALLVDQDVPAQDI
LTQIRAAAGEWLTDLRLFDVYHGKGIDPHRKSLAVGLTWQHPSRTLNDDEVNSTTQNIVT
SLEERFNATLRK
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| BDBM231665 |
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| n/a |
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| Name | BDBM231665 |
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| Synonyms: | 1-(3-(4-(Pyridin-2-yl)piperazin-1-ylsulfonyl)phenyl)-3-(thiazol-2-yl)urea (1a) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N6O3S2 |
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| Mol. Mass. | 444.53 |
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| SMILES | O=C(Nc1nccs1)Nc1cccc(c1)S(=O)(=O)N1CCN(CC1)c1ccccn1 |
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| Structure | 
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