| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein phosphatase 5 |
|---|
| Ligand | BDBM231694 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Phosphatase Inhibition Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 298.15±0 K |
|---|
| IC50 | 7.88e+4± 4.9e+3 nM |
|---|
| Citation |  Bongard, RD; Lepley, M; Thakur, K; Talipov, MR; Nayak, J; Lipinski, RAJ; Bohl, C; Sweeney, N; Ramchandran, R; Rathore, R; Sem, DS Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor. BMC Biochem18:1-15 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein phosphatase 5 |
|---|
| Name: | Dual specificity protein phosphatase 5 |
|---|
| Synonyms: | DUS5_HUMAN | DUSP5 | Dual-specificity phosphatase 5 phophatase (DUSP5) | VH3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42058.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16690 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGP
RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISS
HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
LAPVPTHSTVSELSRSPVATATSC
|
|
|
|---|
| BDBM231694 |
|---|
| n/a |
|---|
| Name | BDBM231694 |
|---|
| Synonyms: | 1-Amin-5-Naphthol-7-Sulfonic acid | NCI2602 | RR535 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H9NO4S |
|---|
| Mol. Mass. | 239.248 |
|---|
| SMILES | Nc1cccc2c(O)cc(cc12)S(O)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
