Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM232263 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In-Vitro Fluorescence Assay |
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pH | 5.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 81±n/a nM |
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Comments | extracted |
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Citation | Klein, M; Tsaklakidis, C; Guehring, H; Leuthner, B Aminostatin derivatives for the treatment of arthrosis US Patent US9345742 Publication Date 5/24/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM232263 |
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n/a |
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Name | BDBM232263 |
Synonyms: | US9345742, 21 |
Type | Small organic molecule |
Emp. Form. | C37H56N6O6 |
Mol. Mass. | 680.8771 |
SMILES | CC[C@H](C)[C@H](NC(=O)C[C@H](N)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)OC |r| |
Structure |
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