Reaction Details |
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Target | N-acylethanolamine-hydrolyzing acid amidase |
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Ligand | BDBM233797 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorogenic Assay |
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pH | 4.5±n/a |
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IC50 | 37±n/a nM |
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Comments | extracted |
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Citation | Piomelli, D; Bandiera, T; Mor, M; Tarzia, G; Bertozzi, F; Ponzano, S Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA) US Patent US9353075 Publication Date 5/31/2016 |
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More Info.: | Get all data from this article, Assay Method |
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N-acylethanolamine-hydrolyzing acid amidase |
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Name: | N-acylethanolamine-hydrolyzing acid amidase |
Synonyms: | ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT |
Type: | Enzyme |
Mol. Mass.: | 40073.12 |
Organism: | Homo sapiens (Human) |
Description: | Q02083 |
Residue: | 359 |
Sequence: | MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLV
RAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAY
ESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGL
WTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKT
PLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDR
RTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
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BDBM233797 |
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n/a |
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Name | BDBM233797 |
Synonyms: | US9353075, 54 |
Type | Small organic molecule |
Emp. Form. | C20H21NO4 |
Mol. Mass. | 339.385 |
SMILES | CC(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1 |r| |
Structure |
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