| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) |
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| Ligand | BDBM236643 |
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| Substrate/Competitor | cAMP |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| IC50 | >50000±n/a nM |
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| Citation |  Piazza, GA; Abadi, AH Derivatives of celeboxib, use thereof and preparation thereof US Patent US9388139 Publication Date 7/12/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) |
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| Name: | Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) |
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| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 (PDE11) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55692.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HCR9-4 |
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| Residue: | 489 |
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| Sequence: | MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI
SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY
DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI
TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG
FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI
LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE
LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS
VMVAKEDRN
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| BDBM236643 |
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| cAMP |
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| Name | BDBM236643 |
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| Synonyms: | US9388139, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20Cl2N2O2 |
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| Mol. Mass. | 391.291 |
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| SMILES | CC(C)(C)C1=NN(C(C1)c1ccc(Cl)cc1Cl)c1ccc(cc1)C(O)=O |t:4| |
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| Structure | 
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