| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM240604 |
|---|
| Substrate/Competitor | US9409882, Z-Val-Val-Arg-AMC |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 6.5±n/a |
|---|
| IC50 | 11.785±n/a nM |
|---|
| Citation |  Anselm, L; Banner, D; Haap, W; Kuhn, B; Luebbers, T; Peters, J; Spinnler, B Pyridine derivatives US Patent US9409882 Publication Date 8/9/2016 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37507.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25774 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
|---|
| BDBM240604 |
|---|
| US9409882, Z-Val-Val-Arg-AMC |
|---|
| Name | BDBM240604 |
|---|
| Synonyms: | US9409882, 9 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H25ClF2N4O2S |
|---|
| Mol. Mass. | 579.06 |
|---|
| SMILES | Fc1ccc(cc1)-c1cccc(S[C@@H]2C[C@H](N(C2)C(=O)C2(CC2)c2ncc(Cl)cc2F)C(=O)NC2(CC2)C#N)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
