| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acid ceramidase |
|---|
| Ligand | BDBM241946 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Acid Ceramidase Activity Assay |
|---|
| pH | 4.5±n/a |
|---|
| IC50 | 14±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Piomelli, D; Realini, N; Mor, M; Pagliuca, C; Pizzirani, D; Scarpelli, R; Bandiera, T Acid ceramidase inhibitors and their use as medicaments US Patent US9428465 Publication Date 8/30/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acid ceramidase |
|---|
| Name: | Acid ceramidase |
|---|
| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44662.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13510 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
|
|
|
|---|
| BDBM241946 |
|---|
| n/a |
|---|
| Name | BDBM241946 |
|---|
| Synonyms: | US9428465, 24 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H24BrN3O5 |
|---|
| Mol. Mass. | 418.283 |
|---|
| SMILES | CCCCCCNC(=O)n1cc(Br)c(=O)n(C(=O)OCC(C)C)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
