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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [368-440] | ||
| Ligand | BDBM249277 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 78.6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [368-440] | |||
| Name: | Bromodomain-containing protein 4 [368-440] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 8564.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD2 (368-440 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM249277 | |||
| n/a | |||
| Name | BDBM249277 | ||
| Synonyms: | US10017501, Compound 1020-18 | US9458145, 1020-18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H22N4O | ||
| Mol. Mass. | 394.4684 | ||
| SMILES | Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(nc2c1)C1CC1 |(1.89,3.57,;.56,4.34,;.08,5.8,;-1.46,5.8,;-1.94,4.34,;-3.27,3.57,;-.69,3.44,;-.69,1.9,;.64,1.13,;.64,-.41,;1.98,-1.18,;3.31,-.41,;3.31,1.13,;4.65,-1.18,;4.65,-2.72,;3.31,-3.49,;3.31,-5.03,;1.98,-5.8,;.64,-5.03,;.64,-3.49,;1.98,-2.72,;-.69,-1.18,;-1.01,-2.69,;-2.54,-2.85,;-3.17,-1.45,;-2.02,-.41,;-2.02,1.13,;-3.31,-4.19,;-4.65,-4.96,;-3.31,-5.73,)| | ||
| Structure | 
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