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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | ||
| Ligand | BDBM254586 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 310.15±n/a K | ||
| IC50 | 32±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martínez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9469597 Publication Date 10/18/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | |||
| Name: | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | ||
| Synonyms: | GST-Lysine Specific Demethylase-1 (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Glutathione S-transferase P | ||
| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 23353.53 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P09211 | ||
| Residue: | 210 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Lysine-specific histone demethylase 1A [158-852] | ||
| Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine Specific Demethylase-1 (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 77140.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 158-852 | ||
| Residue: | 695 | ||
| Sequence: |
| ||
| BDBM254586 | |||
| n/a | |||
| Name | BDBM254586 | ||
| Synonyms: | US10214477, Example 45 | US9469597, 45 | US9670136, 45 3-(5-((trans)-2-((4-aminocyclohexyl)amino)cyclopropyl)thiazol-2-yl)phenol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H23N3OS | ||
| Mol. Mass. | 329.46 | ||
| SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(O)c1 |r,wU:10.12,wD:8.8,(6.65,5.12,;5.31,4.35,;5.31,2.81,;3.98,2.04,;2.64,2.81,;2.64,4.35,;3.98,5.12,;1.31,2.04,;-.02,2.81,;-.79,4.15,;-1.56,2.81,;-2.9,2.04,;-4.36,2.52,;-5.27,1.27,;-4.36,.03,;-2.9,.5,;-4.76,-1.46,;-6.25,-1.86,;-6.65,-3.35,;-5.56,-4.43,;-4.07,-4.04,;-2.98,-5.12,;-3.67,-2.55,)| | ||
| Structure | 
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