Reaction Details |
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Target | Glutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876] |
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Ligand | BDBM256470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 48±n/a nM |
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Comments | extracted |
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Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9487512 Publication Date 11/8/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Glutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876] |
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Name: | Glutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876] |
Synonyms: | GST-Lysine-specific histone demethylase 1A (LSD1) | Glutathione S-transferase P/Lysine-specific histone demethylase 1A (2) [158-876] |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Glutathione S-transferase P |
Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) |
Type: | Enzyme |
Mol. Mass.: | 23353.53 |
Organism: | Homo sapiens (Human) |
Description: | P09211 |
Residue: | 210 |
Sequence: | MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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Component 2 |
Name: | Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876] |
Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A (2) [158-876] | Lysine-specific histone demethylase 1A (LSD1) |
Type: | n/a |
Mol. Mass.: | 79390.01 |
Organism: | Homo sapiens (Human) |
Description: | amino acids 158-end; GenBank accession no. NM_015013, uniprot: O60341-2 from NM_015013 |
Residue: | 719 |
Sequence: | APPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFP
DIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLE
RHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRV
ATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKE
KDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKK
IVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKE
YDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD
QDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQT
FIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDP
SVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKG
IFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPI
PRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
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BDBM256470 |
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n/a |
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Name | BDBM256470 |
Synonyms: | US10329256, Example 15 | US9487512, 15 | US9944601, Example 15 |
Type | Small organic molecule |
Emp. Form. | C17H24N2 |
Mol. Mass. | 256.3859 |
SMILES | C1[C@H](NC2CC3(C2)CCNCC3)[C@H]1c1ccccc1 |r| |
Structure |
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