| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK4 [1-391] |
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| Ligand | BDBM375474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent US10358436 Publication Date 7/23/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK4 [1-391] |
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| Name: | Serine/threonine-protein kinase PLK4 [1-391] |
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| Synonyms: | PLK4 | PLK4_HUMAN | SAK | STK18 | Serine/threonine-protein kinase PLK4 |
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| Type: | Protein |
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| Mol. Mass.: | 43940.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-391 |
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| Residue: | 391 |
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| Sequence: | MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQA
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| BDBM375474 |
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| n/a |
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| Name | BDBM375474 |
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| Synonyms: | US10358436, Example A184 | US9907800, Example A183 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28N4O3S |
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| Mol. Mass. | 512.623 |
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| SMILES | COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5csc(CN6CCOCC6)c5)n[nH]c4c3)c2c1 |r| |
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| Structure | 
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