| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Ligand | BDBM327866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | enzyme-linked immunosorbent assay |
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| EC50 | 750±n/a nM |
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| Citation |  Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent US10377742 Publication Date 8/13/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 62331.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54646 |
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| Residue: | 552 |
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| Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
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| BDBM327866 |
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| n/a |
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| Name | BDBM327866 |
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| Synonyms: | N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(3- benzylphenyl)pyridine- 2,5-dicarboxamide | US10377742, Compound 5 | US9663496, Compound 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H31N5O2 |
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| Mol. Mass. | 529.6315 |
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| SMILES | O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cccc(Cc2ccccc2)c1 |
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| Structure | 
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