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Target5'-AMP-activated protein kinase catalytic subunit alpha-2
LigandBDBM327876
Substrate/Competitorn/a
Meas. Tech.enzyme-linked immunosorbent assay
EC50 3000±n/a nM
Citation Goff, DPayan, DSingh, RShaw, SCarroll, DHitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent US10377742 Publication Date 8/13/2019
More Info.:Get all data from this article,  Assay Method
 
5'-AMP-activated protein kinase catalytic subunit alpha-2
Name:5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:Enzyme
Mol. Mass.:62331.02
Organism:Homo sapiens (Human)
Description:P54646
Residue:552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
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  Blast E-value cutoff:
BDBM327876
n/a
NameBDBM327876
Synonyms:4-((8-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinoyl)- 2,8- diazaspiro[4.5]decan-2- yl)methyl)benzonitrile | US10377742, Compound 15 | US9663496, Compound 15
TypeSmall organic molecule
Emp. Form.C34H37FN6O2
Mol. Mass.580.695
SMILESFc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCC3(CCN(Cc4ccc(cc4)C#N)C3)CC2)cc1
Structure
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