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Target5'-AMP-activated protein kinase catalytic subunit alpha-2
LigandBDBM327899
Substrate/Competitorn/a
Meas. Tech.enzyme-linked immunosorbent assay
EC50 750±n/a nM
Citation Goff, DPayan, DSingh, RShaw, SCarroll, DHitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent US10377742 Publication Date 8/13/2019
More Info.:Get all data from this article,  Assay Method
 
5'-AMP-activated protein kinase catalytic subunit alpha-2
Name:5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:Enzyme
Mol. Mass.:62331.02
Organism:Homo sapiens (Human)
Description:P54646
Residue:552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
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  Blast E-value cutoff:
BDBM327899
n/a
NameBDBM327899
Synonyms:N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4- cyanobenzyl)piperidin-4- yl)pyridine-2,5- dicarboxamide | US10377742, Compound 38 | US9663496, Compound 38
TypeSmall organic molecule
Emp. Form.C31H28N8O2
Mol. Mass.544.6064
SMILESO=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1
Structure
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