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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [866-1154] | ||
| Ligand | BDBM410178 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper mobility shift assay | ||
| IC50 | 34.0±n/a nM | ||
| Citation |  Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent US10370375 Publication Date 8/6/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [866-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [866-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) | ||
| Type: | Protein | ||
| Mol. Mass.: | 33185.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[866-1154] | ||
| Residue: | 289 | ||
| Sequence: |
| ||
| BDBM410178 | |||
| n/a | |||
| Name | BDBM410178 | ||
| Synonyms: | US10370375, Example 26 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H23N5O2S | ||
| Mol. Mass. | 361.462 | ||
| SMILES | CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)C#N |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-3.71,2.56,;-2.38,.25,;-3.71,-.52,;-3.71,-2.06,;-2.38,-2.83,;-1.04,-2.06,;.42,-2.54,;1.33,-1.29,;.42,-.05,;-1.04,-.52,;-5.04,.25,;-6.38,-.52,)| | ||
| Structure | 
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