Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 1 |
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Ligand | BDBM324926 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ubitquin-Rhodamine 110 Assay for USP1 Activity |
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IC50 | <50±n/a nM |
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Citation | Buckmelter, AJ; Ioannidis, S; Follows, B; Gustafson, G; Wang, M; Caravella, JA; Wang, Z; Fritzen, EL; Lin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10399980 Publication Date 9/3/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 1 |
Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP |
Type: | PROTEIN |
Mol. Mass.: | 88191.62 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104169 |
Residue: | 785 |
Sequence: | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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BDBM324926 |
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n/a |
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Name | BDBM324926 |
Synonyms: | 2-(2-(2-hydroxypropan- | US10189841, Compound I-132 | US10399980, Compound I-132 | US11161848, Compound I-132 |
Type | Small organic molecule |
Emp. Form. | C27H25F3N6O2 |
Mol. Mass. | 522.5216 |
SMILES | Cn1cc(nc1-c1ccc(Cn2c3nc(ncc3n(C)c2=O)-c2ccccc2C(C)(C)O)cc1)C(F)(F)F |
Structure |
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