| Reaction Details |
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 | Report a problem with these data |
| Target | Activated CDC42 kinase 1 |
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| Ligand | BDBM419775 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 3.49±n/a nM |
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| Citation |  Lee, H; Chun, K; Joe, B; Kim, ES; Jang, ES; Oh, H; Kim, J; Park, J; Lee, H Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same US Patent US10464919 Publication Date 11/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activated CDC42 kinase 1 |
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| Name: | Activated CDC42 kinase 1 |
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| Synonyms: | ACK1 | ACK1_HUMAN | Activated CDC42 kinase 1 (ACK-1) | TNK2 | Tyrosine kinase non-receptor protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 114577.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07912 |
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| Residue: | 1038 |
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| Sequence: | MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
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| BDBM419775 |
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| n/a |
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| Name | BDBM419775 |
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| Synonyms: | US10464919, Example 113 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26FN5O |
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| Mol. Mass. | 431.5052 |
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| SMILES | C[C@H]1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(C#N)c(F)c1 |r| |
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| Structure | 
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