Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-3

Ligand

BDBM377190

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Assay

IC50

<100±n/a nM

Citation

Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent US10517858 Publication Date 12/31/2019

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-3

Name:

Serine/threonine-protein kinase pim-3

Synonyms:

PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)

Type:

Protein

Mol. Mass.:

35888.19

Organism:

Homo sapiens (Human)

Description:

Q86V86

Residue:

326

Sequence:

MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL

BDBM377190

n/a

Name

BDBM377190

Synonyms:

N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 39 | US10517858, Example 39 | US10828290, Example 39 | US11229631, Example 39

Type

Small organic molecule

Emp. Form.

C25H24F3N5O2

Mol. Mass.

483.4856

SMILES

C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|

Structure