Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1

Ligand

BDBM428998

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Anisotropy Competition Assay

<50.0±n/a nM

Citation

Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10533010 Publication Date 1/14/2020

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Synonyms:

Type:

Membrane; Single-pass membrane protein

Mol. Mass.:

37332.87

Organism:

Homo sapiens (Human)

Description:

Q07820

Residue:

350

Sequence:

MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM428998

n/a

Name

BDBM428998

Synonyms:

US10533010, Example I-91 | US11208415, Example I-91

Type

Small organic molecule

Emp. Form.

C37H39Cl2N5O5

Mol. Mass.

704.642

SMILES

Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)Nc1ccc(C(O)=O)c(c1)N1CCOCC1 |(-2.56,5.31,;-3.89,6.08,;-4.37,7.54,;-5.91,7.54,;-6.68,8.88,;-6.38,6.08,;-7.72,5.31,;-5.14,5.17,;-5.14,3.63,;-6.47,2.86,;-7.81,3.63,;-6.47,1.32,;-5.14,.55,;-3.8,1.32,;-2.34,.85,;-1.94,-.64,;-.45,-1.04,;-.06,-2.53,;1.43,-2.93,;1.83,-4.41,;3.32,-4.81,;3.72,-6.3,;5.2,-6.7,;2.63,-7.39,;3.03,-8.88,;1.14,-6.99,;.05,-8.08,;.74,-5.5,;-1.43,2.09,;-2.34,3.34,;-3.8,2.86,;.11,2.09,;.88,.76,;.88,3.43,;2.42,3.43,;3.19,2.09,;4.73,2.09,;5.55,3.43,;7.09,3.43,;7.86,2.09,;7.86,4.76,;4.73,4.76,;3.19,4.76,;5.5,6.09,;7.04,6.09,;7.81,7.43,;7.04,8.76,;5.5,8.76,;4.73,7.43,)|

Structure