Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1

Ligand

BDBM429035

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Anisotropy Competition Assay

<50.0±n/a nM

Citation

Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10533010 Publication Date 1/14/2020

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Synonyms:

Type:

Membrane; Single-pass membrane protein

Mol. Mass.:

37332.87

Organism:

Homo sapiens (Human)

Description:

Q07820

Residue:

350

Sequence:

MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM429035

n/a

Name

BDBM429035

Synonyms:

US10533010, Example I-132 | US11208415, Example I-132

Type

Small organic molecule

Emp. Form.

C36H38Cl2N4O5

Mol. Mass.

677.617

SMILES

CC1CN(Cc2ccc(o2)C(O)=O)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n2C1 |(-.75,7.04,;-.75,5.5,;.6,4.77,;.88,3.25,;2.36,2.85,;3.45,3.94,;2.98,5.41,;4.22,6.31,;5.51,5.42,;4.99,3.94,;6.97,5.9,;7.29,7.4,;8.12,4.87,;-.14,2.09,;.63,.76,;-1.67,2.09,;-2.58,.85,;-2.18,-.64,;-.69,-1.04,;-.3,-2.53,;1.19,-2.93,;1.59,-4.41,;3.08,-4.81,;3.48,-6.3,;4.96,-6.7,;2.39,-7.39,;2.79,-8.88,;.9,-6.99,;-.19,-8.08,;.5,-5.5,;-4.04,1.32,;-5.38,.55,;-6.71,1.32,;-6.71,2.86,;-8.05,3.63,;-5.38,3.63,;-5.38,5.17,;-4.13,6.08,;-2.8,5.31,;-4.61,7.54,;-6.15,7.54,;-6.92,8.88,;-6.62,6.08,;-7.96,5.31,;-4.04,2.86,;-2.58,3.34,;-2.17,4.89,)|

Structure