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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM429181 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization Anisotropy Competition Assay | ||
| Ki | <50.0±n/a nM | ||
| Citation |  Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10533010 Publication Date 1/14/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
| ||
| BDBM429181 | |||
| n/a | |||
| Name | BDBM429181 | ||
| Synonyms: | US10533010, Example I-309 | US11208415, Example I-309 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C50H49Cl2N5O6S | ||
| Mol. Mass. | 918.925 | ||
| SMILES | Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c3C(=O)N(Cc4ccc(cc4)C(=O)NS(=O)(=O)c4ccc(OCc5ccccc5)cc4)CCCn3c12 |(-6.14,4.12,;-7.48,4.89,;-7.95,6.35,;-9.49,6.35,;-10.26,7.69,;-9.97,4.89,;-11.3,4.12,;-8.72,3.98,;-8.72,2.44,;-10.06,1.67,;-11.39,2.44,;-10.06,.13,;-8.72,-.64,;-7.39,.13,;-5.93,-.34,;-5.53,-1.83,;-4.04,-2.23,;-3.64,-3.72,;-2.15,-4.11,;-1.75,-5.6,;-.27,-6,;.13,-7.49,;1.62,-7.89,;-.96,-8.58,;-.56,-10.07,;-2.45,-8.18,;-3.53,-9.27,;-2.84,-6.69,;-5.02,.9,;-3.48,.9,;-2.71,-.43,;-2.47,2.06,;-.93,2.06,;-.16,3.4,;1.38,3.4,;2.15,4.73,;1.38,6.06,;-.16,6.06,;-.93,4.73,;2.15,7.4,;1.38,8.73,;3.69,7.4,;4.46,8.73,;3.13,9.5,;5.23,10.07,;6,8.73,;6.77,7.4,;8.31,7.4,;9.08,8.73,;10.62,8.73,;11.39,7.4,;10.62,6.06,;9.08,6.06,;8.31,4.73,;9.08,3.4,;10.62,3.4,;11.39,4.73,;8.31,10.07,;6.77,10.07,;-2.74,3.58,;-4.1,4.31,;-5.52,3.7,;-5.93,2.15,;-7.39,1.67,)| | ||
| Structure | 
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