Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1

Ligand

BDBM429187

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Anisotropy Competition Assay

<50.0±n/a nM

Citation

Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10533010 Publication Date 1/14/2020

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Synonyms:

Type:

Membrane; Single-pass membrane protein

Mol. Mass.:

37332.87

Organism:

Homo sapiens (Human)

Description:

Q07820

Residue:

350

Sequence:

MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM429187

n/a

Name

BDBM429187

Synonyms:

US10533010, Example I-318 | US11208415, Example I-318

Type

Small organic molecule

Emp. Form.

C34H40ClN5O5

Mol. Mass.

634.165

SMILES

Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)NC1CCN(CC1)C(=O)CC(O)=O |(-3.76,5.31,;-5.09,6.08,;-5.57,7.54,;-7.11,7.54,;-7.88,8.88,;-7.58,6.08,;-8.92,5.31,;-6.34,5.17,;-6.34,3.63,;-7.67,2.86,;-7.67,1.32,;-6.34,.55,;-5,1.32,;-3.54,.85,;-3.14,-.64,;-1.65,-1.04,;-1.25,-2.53,;.23,-2.93,;.63,-4.41,;2.12,-4.81,;2.52,-6.3,;4.01,-6.7,;1.43,-7.39,;1.83,-8.88,;-.06,-6.99,;-1.15,-8.08,;-.46,-5.5,;-2.63,2.09,;-3.54,3.34,;-5,2.86,;-1.09,2.09,;-.32,.76,;-.32,3.43,;1.22,3.43,;1.99,2.09,;3.53,2.09,;4.3,3.43,;3.53,4.76,;1.99,4.76,;5.84,3.43,;6.61,4.76,;6.61,2.09,;8.15,2.09,;8.92,.76,;8.92,3.43,)|

Structure