Ki Summary

Reaction Details

Report a problem with these data

Target

Induced myeloid leukemia cell differentiation protein Mcl-1

Ligand

BDBM428986

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Anisotropy Competition Assay

10.00±n/a nM

Citation

Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10533010 Publication Date 1/14/2020

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Synonyms:

Type:

Membrane; Single-pass membrane protein

Mol. Mass.:

37332.87

Organism:

Homo sapiens (Human)

Description:

Q07820

Residue:

350

Sequence:

MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM428986

n/a

Name

BDBM428986

Synonyms:

US10533010, Example I-71 | US11208415, Example I-71

Type

Small organic molecule

Emp. Form.

C32H34ClN5O4

Mol. Mass.

588.096

SMILES

Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)NCc1c[nH]c(c1)C(O)=O |(-2.63,5.31,;-3.97,6.08,;-4.44,7.54,;-5.98,7.54,;-6.75,8.88,;-6.46,6.08,;-7.79,5.31,;-5.21,5.17,;-5.21,3.63,;-6.55,2.86,;-6.55,1.32,;-5.21,.55,;-3.88,1.32,;-2.42,.85,;-2.02,-.64,;-.53,-1.04,;-.13,-2.53,;1.36,-2.93,;1.76,-4.41,;3.24,-4.81,;3.64,-6.3,;5.13,-6.7,;2.55,-7.39,;2.95,-8.88,;1.07,-6.99,;-.02,-8.08,;.67,-5.5,;-1.51,2.09,;-2.42,3.34,;-3.88,2.86,;.03,2.09,;.8,.76,;.8,3.43,;2.34,3.43,;3.11,2.09,;2.63,.63,;3.88,-.28,;5.13,.63,;4.65,2.09,;6.46,-.14,;6.46,-1.68,;7.79,.63,)|

Structure