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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM165348 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.15±n/a nM | ||
| Comments | extracted | ||
| Citation |  Liu, Q; Watterson, SH; Ahmad, S Indole carboxamide compounds US Patent US9688629 Publication Date 6/27/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM165348 | |||
| n/a | |||
| Name | BDBM165348 | ||
| Synonyms: | US10604504, Example 132 | US11623921, Example 132 | US9688629, 132 | US9802915, Example 132 | US9920031, Example 132 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H20FN3O2 | ||
| Mol. Mass. | 377.4115 | ||
| SMILES | Cc1[nH]c2c(cc(F)c(-c3cccc4CN(Cc34)C(=O)C=C)c2c1C)C(N)=O |(-6.4,1.15,;-4.86,1.15,;-3.95,2.4,;-2.49,1.93,;-1.15,2.69,;.18,1.93,;.18,.38,;1.51,-.38,;-1.15,-.38,;-1.15,-1.93,;-2.49,-2.69,;-2.49,-4.23,;-1.15,-5,;.18,-4.23,;1.64,-4.71,;2.55,-3.47,;1.64,-2.22,;.18,-2.69,;4.09,-3.47,;4.86,-2.13,;4.86,-4.8,;6.4,-4.8,;-2.49,.38,;-3.95,-.09,;-4.41,-1.42,;-1.15,4.23,;.18,5,;-2.49,5,)| | ||
| Structure | 
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