Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM166011 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.20±n/a nM | ||
Comments | extracted | ||
Citation | Liu, Q; Watterson, SH; Ahmad, S Indole carboxamide compounds US Patent US9688629 Publication Date 6/27/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM166011 | |||
n/a | |||
Name | BDBM166011 | ||
Synonyms: | US10604504, Example 211 | US11623921, Example 211 | US9688629, 209 | US9688629, 210 | US9688629, 211 | US9802915, Example 209 | US9920031, Example 211 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H24FN3O2 | ||
Mol. Mass. | 417.4754 | ||
SMILES | Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C1CC1)C(N)=O |(-6.62,1.93,;-5.08,1.93,;-4.18,3.17,;-2.71,2.69,;-1.38,3.47,;-.05,2.69,;-.05,1.15,;1.29,.38,;-1.38,.38,;-1.38,-1.15,;-2.71,-1.93,;-2.71,-3.47,;-1.38,-4.23,;-.05,-3.47,;1.29,-4.23,;2.62,-3.47,;2.62,-1.93,;1.29,-1.15,;-.05,-1.93,;3.96,-4.23,;3.96,-5.78,;5.29,-3.47,;6.62,-4.23,;-2.71,1.15,;-4.18,.68,;-4.58,-.81,;-5.67,-1.9,;-4.18,-2.3,;-1.38,5,;-.05,5.78,;-2.71,5.78,)| | ||
Structure |