Reaction Details | |||
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Target | Lysine-specific histone demethylase 1A | ||
Ligand | BDBM439101 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FL-LSD1 LC-MS Assay | ||
IC50 | 4.00±n/a nM | ||
Citation | Du-Cuny, L; Xiao, Q; Xun, G; Zheng, Q Substituted 5-cyanoindole compounds and uses thereof US Patent US10604502 Publication Date 3/31/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A | |||
Name: | Lysine-specific histone demethylase 1A | ||
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 92901.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60341 | ||
Residue: | 852 | ||
Sequence: |
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BDBM439101 | |||
n/a | |||
Name | BDBM439101 | ||
Synonyms: | 3-(2,2-dimethyl-1,2,3,4-tetrahydro-1,7-naphthyridin-5-yl)-1-((1R,4R)-4-hydroxycyclohexyl)-6-methyl-1H-indole-5-carbonitrile | US10604502, Ex # 89 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H30N4O | ||
Mol. Mass. | 414.5426 | ||
SMILES | Cc1cc2n(cc(-c3cncc4NC(C)(C)CCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:27.31,(-6.1,.69,;-4.64,1.16,;-3.49,.13,;-2.03,.61,;-.69,-.16,;.45,.87,;-.17,2.28,;.6,3.61,;-.17,4.94,;.6,6.28,;2.14,6.28,;2.91,4.94,;4.45,4.94,;5.22,3.61,;6.55,4.38,;6.55,2.84,;4.45,2.28,;2.91,2.28,;2.14,3.61,;-1.71,2.12,;-2.85,3.15,;-4.32,2.67,;-5.46,3.7,;-6.55,4.79,;-.53,-1.69,;.88,-2.3,;1.07,-3.82,;-.16,-4.75,;.02,-6.28,;-1.58,-4.14,;-1.76,-2.62,)| | ||
Structure |