Compile Data Set for Download or QSAR

Found 609 hits with Last Name = 'xun' and Initial = 'g'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99280 (US8497368, 72) Show SMILES CC(=NNC(N)=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:2.2| Show InChI InChI=1S/C17H14FN9O/c1-9(23-25-17(19)28)14-7-21-15-16(22-14)27(26-24-15)8-11-5-10-3-2-4-20-13(10)6-12(11)18/h2-7H,8H2,1H3,(H3,19,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99254 (US8497368, 46) Show SMILES C[C@H](c1nnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1 |r,w:13.15| Show InChI InChI=1S/C19H18N8O/c1-11(13-5-6-16-14(10-13)4-3-9-21-16)18-24-23-17-8-7-15(26-27(17)18)12(2)22-25-19(20)28/h3-11H,1-2H3,(H3,20,25,28)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99273 (US8497368, 65) Show SMILES NC(=O)NNC(=N)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C16H14N10O/c17-13(22-24-16(18)27)12-7-20-14-15(21-12)26(25-23-14)8-9-3-4-11-10(6-9)2-1-5-19-11/h1-7H,8H2,(H2,17,22)(H3,18,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99248 (US8497368, 40) Show SMILES CC(=NNC(N)=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 |w:2.2| Show InChI InChI=1S/C18H14F2N8O/c1-9(23-26-18(21)29)13-4-5-15-24-25-16(28(15)27-13)7-11-12(19)8-14-10(17(11)20)3-2-6-22-14/h2-6,8H,7H2,1H3,(H3,21,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99274 (US8497368, 66) Show SMILES NC(=O)NN=Cc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 |w:5.5| Show InChI InChI=1S/C16H13N9O/c17-16(26)23-20-8-12-7-19-14-15(21-12)25(24-22-14)9-10-3-4-13-11(6-10)2-1-5-18-13/h1-8H,9H2,(H3,17,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99238 (US8497368, 30) Show SMILES C[C@H](c1cnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1 |r,w:13.15| Show InChI InChI=1S/C20H19N7O/c1-12(14-5-6-17-15(10-14)4-3-9-22-17)18-11-23-19-8-7-16(26-27(18)19)13(2)24-25-20(21)28/h3-12H,1-2H3,(H3,21,25,28)/t12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99228 (US8497368, 20) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 |w:2.2| Show InChI InChI=1S/C19H15F2N7O/c1-10(25-26-19(22)29)15-4-5-17-24-9-11(28(17)27-15)7-13-14(20)8-16-12(18(13)21)3-2-6-23-16/h2-6,8-9H,7H2,1H3,(H3,22,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100728 (US8507676, 78) Show SMILES CC(N=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 Show InChI InChI=1S/C17H12F2N6O/c1-9(24-26)13-4-5-15-21-22-16(25(15)23-13)7-11-12(18)8-14-10(17(11)19)3-2-6-20-14/h2-6,8-9H,7H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99281 (US8497368, 73) Show SMILES CC(=O)NN=C(C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:4.3| Show InChI InChI=1S/C18H15FN8O/c1-10(23-24-11(2)28)16-8-21-17-18(22-16)27(26-25-17)9-13-6-12-4-3-5-20-15(12)7-14(13)19/h3-8H,9H2,1-2H3,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100726 (US8507676, 77-S) Show SMILES C[C@@H](c1nnc2ccc(nn12)C(C)=NOC(N)=O)c1c(F)cc2ncccc2c1F |r,w:13.15| Show InChI InChI=1S/C19H15F2N7O2/c1-9(16-12(20)8-14-11(17(16)21)4-3-7-23-14)18-25-24-15-6-5-13(26-28(15)18)10(2)27-30-19(22)29/h3-9H,1-2H3,(H2,22,29)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99257 (US8497368, 49) Show SMILES CC(c1nnc2ccc(nn12)C(C)=NNC(N)=O)c1c(F)cc2ncccc2c1F |w:13.15| Show InChI InChI=1S/C19H16F2N8O/c1-9(16-12(20)8-14-11(17(16)21)4-3-7-23-14)18-26-25-15-6-5-13(28-29(15)18)10(2)24-27-19(22)30/h3-9H,1-2H3,(H3,22,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99283 (US8497368, 75) Show SMILES CC(=NNC(=O)c1ccncc1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:2.2| Show InChI InChI=1S/C22H16FN9O/c1-13(28-30-22(33)14-4-7-24-8-5-14)19-11-26-20-21(27-19)32(31-29-20)12-16-9-15-3-2-6-25-18(15)10-17(16)23/h2-11H,12H2,1H3,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99241 (US8497368, 33) Show SMILES CC(=NNC(N)=O)c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1 |w:2.2| Show InChI InChI=1S/C18H14F2N8O/c1-10(23-26-17(21)29)13-6-7-15-24-25-16(28(15)27-13)18(19,20)12-4-5-14-11(9-12)3-2-8-22-14/h2-9H,1H3,(H3,21,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99268 (US8497368, 60) Show SMILES CN(N=C(C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1)C(N)=O |w:2.1| Show InChI InChI=1S/C18H17N9O/c1-11(24-26(2)18(19)28)15-9-21-16-17(22-15)27(25-23-16)10-12-5-6-14-13(8-12)4-3-7-20-14/h3-9H,10H2,1-2H3,(H2,19,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99284 (US8497368, 76) Show SMILES CC(=Nn1cc(O)[nH]c1=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:2.2| Show InChI InChI=1S/C19H14FN9O2/c1-10(26-29-9-16(30)24-19(29)31)15-7-22-17-18(23-15)28(27-25-17)8-12-5-11-3-2-4-21-14(11)6-13(12)20/h2-7,9,30H,8H2,1H3,(H,24,31)/b26-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439100 (US10604502, Ex # 88) Show SMILES Cc1cc2n(cc(-c3cncc4NC(C)(C)C=Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:27.31,c:16,(-6.1,.69,;-4.64,1.16,;-3.49,.13,;-2.03,.61,;-.69,-.16,;.45,.87,;-.17,2.28,;.6,3.61,;-.17,4.94,;.6,6.28,;2.14,6.28,;2.91,4.94,;4.45,4.94,;5.22,3.61,;6.55,4.38,;6.55,2.84,;4.45,2.28,;2.91,2.28,;2.14,3.61,;-1.71,2.12,;-2.85,3.15,;-4.32,2.67,;-5.46,3.7,;-6.55,4.79,;-.53,-1.69,;.88,-2.3,;1.07,-3.82,;-.16,-4.75,;.02,-6.28,;-1.58,-4.14,;-1.76,-2.62,)| Show InChI InChI=1S/C26H28N4O/c1-16-10-25-21(11-17(16)12-27)23(15-30(25)18-4-6-19(31)7-5-18)22-13-28-14-24-20(22)8-9-26(2,3)29-24/h8-11,13-15,18-19,29,31H,4-7H2,1-3H3/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99218 (US8497368, 8) Show SMILES CN(N=C(C)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1)C(N)=O |w:2.1| Show InChI InChI=1S/C20H18FN7O/c1-12(25-27(2)20(22)29)17-5-6-19-24-11-15(28(19)26-17)9-14-8-13-4-3-7-23-18(13)10-16(14)21/h3-8,10-11H,9H2,1-2H3,(H2,22,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99245 (US8497368, 37) Show SMILES CC(=NNC(N)=O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 |w:2.2| Show InChI InChI=1S/C18H16N8O/c1-11(21-24-18(19)27)14-6-7-16-22-23-17(26(16)25-14)10-12-4-5-15-13(9-12)3-2-8-20-15/h2-9H,10H2,1H3,(H3,19,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99221 (US8497368, 11) Show SMILES C\C(=N/N1CC(=O)NC1=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 Show InChI InChI=1S/C21H16FN7O2/c1-12(26-28-11-20(30)25-21(28)31)17-4-5-19-24-10-15(29(19)27-17)8-14-7-13-3-2-6-23-18(13)9-16(14)22/h2-7,9-11,30H,8H2,1H3,(H,25,31)/b26-12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99286 (US8497368, 78) Show SMILES CC(=NNC(=O)c1cccnc1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:2.2| Show InChI InChI=1S/C22H16FN9O/c1-13(28-30-22(33)15-5-2-6-24-10-15)19-11-26-20-21(27-19)32(31-29-20)12-16-8-14-4-3-7-25-18(14)9-17(16)23/h2-11H,12H2,1H3,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99252 (US8497368, 44) Show SMILES CC(=NN1CCOC1=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 |w:2.2| Show InChI InChI=1S/C20H15F2N7O2/c1-11(26-28-7-8-31-20(28)30)15-4-5-17-24-25-18(29(17)27-15)9-13-14(21)10-16-12(19(13)22)3-2-6-23-16/h2-6,10H,7-9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99211 (US8497368, 1 | US8497368, 17 | US8497368, 18) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 |w:2.2| Show InChI InChI=1S/C19H16FN7O/c1-11(24-25-19(21)28)16-4-5-18-23-10-14(27(18)26-16)8-13-7-12-3-2-6-22-17(12)9-15(13)20/h2-7,9-10H,8H2,1H3,(H3,21,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439120 (US10604502, Ex # 108) Show SMILES CN(C)S(=O)(=O)[C@H]1CC[C@@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12 |r,wU:9.12,wD:6.5,(5.64,-4.74,;4.55,-5.83,;4.95,-7.32,;3.06,-5.43,;1.58,-5.03,;1.97,-6.52,;2.59,-3.96,;3.62,-2.82,;3.14,-1.36,;1.64,-1.04,;.61,-2.18,;1.08,-3.64,;1.16,.43,;2.06,1.68,;1.16,2.92,;1.64,4.39,;.61,5.53,;1.08,6.99,;2.59,7.32,;3.62,6.17,;5.12,6.49,;3.14,4.71,;4.17,3.56,;-.31,2.45,;-1.64,3.22,;-2.97,2.45,;-4.31,3.22,;-5.64,3.99,;-2.97,.91,;-4.31,.14,;-1.64,.14,;-.31,.91,)| Show InChI InChI=1S/C23H26ClN5O2S/c1-14-8-22-18(9-15(14)10-25)20(19-11-27-12-21(26)23(19)24)13-29(22)16-4-6-17(7-5-16)32(30,31)28(2)3/h8-9,11-13,16-17H,4-7,26H2,1-3H3/t16-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99282 (US8497368, 74) Show SMILES COC(=O)NN=C(C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:5.4| Show InChI InChI=1S/C18H15FN8O2/c1-10(23-25-18(28)29-2)15-8-21-16-17(22-15)27(26-24-16)9-12-6-11-4-3-5-20-14(11)7-13(12)19/h3-8H,9H2,1-2H3,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99211 (US8497368, 1 | US8497368, 17 | US8497368, 18) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 |w:2.2| Show InChI InChI=1S/C19H16FN7O/c1-11(24-25-19(21)28)16-4-5-18-23-10-14(27(18)26-16)8-13-7-12-3-2-6-22-17(12)9-15(13)20/h2-7,9-10H,8H2,1H3,(H3,21,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100724 (US8507676, 75-S) Show SMILES CC(N=O)c1ccc2nnc([C@@H](C)c3c(F)cc4ncccc4c3F)n2n1 |r| Show InChI InChI=1S/C18H14F2N6O/c1-9(16-12(19)8-14-11(17(16)20)4-3-7-21-14)18-23-22-15-6-5-13(10(2)25-27)24-26(15)18/h3-10H,1-2H3/t9-,10?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100659 (US8507676, 8) Show SMILES CO\N=C(/C)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 Show InChI InChI=1S/C19H15F2N5O/c1-11(25-27-2)16-5-6-18-23-10-12(26(18)24-16)8-14-15(20)9-17-13(19(14)21)4-3-7-22-17/h3-7,9-10H,8H2,1-2H3/b25-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439039 (US10604502, Ex # 27) Show SMILES Cc1cc2n(cc(-c3c(C)c(N)ccc3F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1 |r,wU:21.23,24.27,(-4.05,-.81,;-2.71,-.04,;-1.38,-.81,;-.05,-.04,;1.42,-.51,;2.32,.73,;1.42,1.98,;1.89,3.44,;3.4,3.76,;4.43,2.62,;3.88,5.23,;5.38,5.55,;2.85,6.37,;1.34,6.05,;.86,4.59,;-.64,4.27,;-.05,1.5,;-1.38,2.27,;-2.71,1.5,;-4.05,2.27,;-5.38,3.04,;1.89,-1.98,;.86,-3.12,;1.34,-4.59,;2.85,-4.91,;3.32,-6.37,;3.88,-3.76,;3.4,-2.3,)| Show InChI InChI=1S/C23H24FN3O/c1-13-9-22-18(10-15(13)11-25)19(23-14(2)21(26)8-7-20(23)24)12-27(22)16-3-5-17(28)6-4-16/h7-10,12,16-17,28H,3-6,26H2,1-2H3/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439089 (US10604502, Ex # 77) Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C22H17ClN4O2S/c1-13-7-21-17(8-14(13)9-24)19(18-10-26-11-20(25)22(18)23)12-27(21)15-3-5-16(6-4-15)30(2,28)29/h3-8,10-12H,25H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99227 (US8497368, 19) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1 |w:2.2| Show InChI InChI=1S/C19H17N7O/c1-12(23-24-19(20)27)16-6-7-18-22-11-15(26(18)25-16)10-13-4-5-17-14(9-13)3-2-8-21-17/h2-9,11H,10H2,1H3,(H3,20,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99233 (US8497368, 25) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(C(O)c3c(F)cc4ncccc4c3F)n2n1 |w:2.2| Show InChI InChI=1S/C19H15F2N7O2/c1-9(25-26-19(22)30)12-4-5-15-24-8-14(28(15)27-12)18(29)16-11(20)7-13-10(17(16)21)3-2-6-23-13/h2-8,18,29H,1H3,(H3,22,26,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439014 (US10604502, Ex # 2) Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](O)CC1 |r,wU:20.22,23.26,(-4.05,-.81,;-2.71,-.04,;-1.38,-.81,;-.05,-.04,;1.42,-.51,;2.32,.73,;1.42,1.98,;1.89,3.44,;.86,4.59,;1.34,6.05,;2.85,6.37,;3.88,5.23,;5.38,5.55,;3.4,3.76,;4.43,2.62,;-.05,1.5,;-1.38,2.27,;-2.71,1.5,;-4.05,2.27,;-5.38,3.04,;1.89,-1.98,;.86,-3.12,;1.34,-4.59,;2.85,-4.91,;3.32,-6.37,;3.88,-3.76,;3.4,-2.3,)| Show InChI InChI=1S/C21H21ClN4O/c1-12-6-20-16(7-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-2-4-15(27)5-3-14/h6-7,9-11,14-15,27H,2-5,24H2,1H3/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100674 (US8507676, 23) Show SMILES C\C(=N/OCCO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C18H17N7O2/c1-12(23-27-8-7-26)16-10-20-17-18(21-16)25(24-22-17)11-13-4-5-15-14(9-13)3-2-6-19-15/h2-6,9-10,26H,7-8,11H2,1H3/b23-12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100673 (US8507676, 22) Show SMILES CO\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C17H15N7O/c1-11(22-25-2)15-9-19-16-17(20-15)24(23-21-16)10-12-5-6-14-13(8-12)4-3-7-18-14/h3-9H,10H2,1-2H3/b22-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100663 (US8507676, 12-S) Show SMILES C[C@H](c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r| Show InChI InChI=1S/C21H19F2N5O2/c1-12(20-15(22)10-17-14(21(20)23)4-3-7-24-17)18-11-25-19-6-5-16(26-28(18)19)13(2)27-30-9-8-29/h3-7,10-12,29H,8-9H2,1-2H3/b27-13+/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100707 (US8507676, 56) Show SMILES C\C(=N/OCCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 Show InChI InChI=1S/C20H18F2N6O2/c1-12(27-30-9-3-8-29)16-5-6-18-24-25-19(28(18)26-16)10-14-15(21)11-17-13(20(14)22)4-2-7-23-17/h2,4-7,11,29H,3,8-10H2,1H3/b27-12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100703 (US8507676, 51-R | US8507676, 51-S) Show SMILES CC(c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2n(C)ncc2c1F Show InChI InChI=1S/C20H20F2N6O2/c1-11(19-14(21)8-16-13(20(19)22)9-24-27(16)3)17-10-23-18-5-4-15(25-28(17)18)12(2)26-30-7-6-29/h4-5,8-11,29H,6-7H2,1-3H3/b26-12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100666 (US8507676, 15) Show SMILES C\C(=N/OCCO)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 Show InChI InChI=1S/C18H16FN7O2/c1-11(24-28-6-5-27)16-9-21-17-18(22-16)26(25-23-17)10-13-7-12-3-2-4-20-15(12)8-14(13)19/h2-4,7-9,27H,5-6,10H2,1H3/b24-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100705 (US8507676, 54 | US8507676, 69) Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 Show InChI InChI=1S/C19H16F2N6O2/c1-11(26-29-8-7-28)15-4-5-17-23-24-18(27(17)25-15)9-13-14(20)10-16-12(19(13)21)3-2-6-22-16/h2-6,10,28H,7-9H2,1H3/b26-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100675 (US8507676, 24) Show SMILES CC(N=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C16H13N7O/c1-10(21-24)14-8-18-15-16(19-14)23(22-20-15)9-11-4-5-13-12(7-11)3-2-6-17-13/h2-8,10H,9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99275 (US8497368, 67) Show SMILES CC(c1cc2cccnc2cc1F)n1nnc2ncc(nc12)C(C)=NNC(N)=O |w:24.28| Show InChI InChI=1S/C18H16FN9O/c1-9(24-26-18(20)29)15-8-22-16-17(23-15)28(27-25-16)10(2)12-6-11-4-3-5-21-14(11)7-13(12)19/h3-8,10H,1-2H3,(H3,20,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99260 (US8497368, 52) Show SMILES CC(=NNC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 |w:2.2| Show InChI InChI=1S/C17H15N9O/c1-10(22-24-17(18)27)14-8-20-15-16(21-14)26(25-23-15)9-11-4-5-13-12(7-11)3-2-6-19-13/h2-8H,9H2,1H3,(H3,18,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99240 (US8497368, 32) Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3c(F)cc4n(C)ncc4c3F)n2n1 |w:2.2| Show InChI InChI=1S/C18H16F2N8O/c1-9(24-25-18(21)29)14-3-4-16-22-7-10(28(16)26-14)5-11-13(19)6-15-12(17(11)20)8-23-27(15)2/h3-4,6-8H,5H2,1-2H3,(H3,21,25,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439109 (3-(2,2-dimethyl-1,2,3,4-tetrahydroquinolin-5-yl)-1...) Show SMILES Cc1cc2n(cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:27.31,(-6.2,.68,;-4.74,1.16,;-3.59,.13,;-2.13,.61,;-.8,-.16,;.35,.87,;-.28,2.27,;.49,3.61,;-.28,4.94,;.49,6.27,;2.03,6.27,;2.8,4.94,;4.34,4.94,;5.11,3.61,;6.65,3.61,;5.88,4.94,;4.34,2.27,;2.8,2.27,;2.03,3.61,;-1.81,2.11,;-2.95,3.14,;-4.42,2.67,;-5.56,3.7,;-6.65,4.79,;-.64,-1.7,;.79,-2.28,;.99,-3.81,;-.23,-4.75,;-.02,-6.27,;-1.65,-4.16,;-1.86,-2.64,)| Show InChI InChI=1S/C27H31N3O/c1-17-13-26-23(14-18(17)15-28)24(16-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-22(21)11-12-27(2,3)29-25/h4-6,13-14,16,19-20,29,31H,7-12H2,1-3H3/t19-,20-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020) BindingDB Entry DOI: 10.7270/Q2MW2M62
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99229 (US8497368, 21) Show SMILES CN(N=C(C)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1)C(N)=O |w:2.1| Show InChI InChI=1S/C20H17F2N7O/c1-11(26-28(2)20(23)30)16-5-6-18-25-10-12(29(18)27-16)8-14-15(21)9-17-13(19(14)22)4-3-7-24-17/h3-7,9-10H,8H2,1-2H3,(H2,23,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99220 (US8497368, 10) Show SMILES CC(=NN1CCOC1=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 |w:2.2| Show InChI InChI=1S/C21H17FN6O2/c1-13(25-27-7-8-30-21(27)29)18-4-5-20-24-12-16(28(20)26-18)10-15-9-14-3-2-6-23-19(14)11-17(15)22/h2-6,9,11-12H,7-8,10H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM99213 (US8497368, 3) Show SMILES CC(=O)NN=C(C)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 |w:4.3| Show InChI InChI=1S/C20H17FN6O/c1-12(24-25-13(2)28)18-5-6-20-23-11-16(27(20)26-18)9-15-8-14-4-3-7-22-19(14)10-17(15)21/h3-8,10-11H,9H2,1-2H3,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8497368 (2013) BindingDB Entry DOI: 10.7270/Q2KW5DN7
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM2214 (US8507676, 53-S) Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r| Show InChI InChI=1S/C20H18F2N6O2/c1-11(18-14(21)10-16-13(19(18)22)4-3-7-23-16)20-25-24-17-6-5-15(26-28(17)20)12(2)27-30-9-8-29/h3-7,10-11,29H,8-9H2,1-2H3/b27-12+/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM100691 (US8507676, 38) Show SMILES OCCO\N=C\c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C17H15N7O2/c25-6-7-26-20-10-14-9-19-16-17(21-14)24(23-22-16)11-12-3-4-15-13(8-12)2-1-5-18-15/h1-5,8-10,25H,6-7,11H2/b20-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM2221 (US8507676, 80) Show SMILES C\C(=N/O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 Show InChI InChI=1S/C17H14N6O/c1-11(22-24)14-6-7-16-19-20-17(23(16)21-14)10-12-4-5-15-13(9-12)3-2-8-18-15/h2-9,24H,10H2,1H3/b22-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...				US Patent US8507676 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RC9
					More data for this Ligand-Target Pair

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