| Reaction Details |
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 | Report a problem with these data |
| Target | OTU domain-containing protein 7B |
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| Ligand | BDBM443251 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Kemp, MI; Stockley, ML; Woodrow, MD; Jones, A Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors US Patent US10654853 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| OTU domain-containing protein 7B |
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| Name: | OTU domain-containing protein 7B |
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| Synonyms: | Cellular zinc finger anti-NF-kappa-B protein | Cezanne | OTU7B_HUMAN | OTUD7B | ZA20D1 | Zinc finger A20 domain-containing protein 1 | Zinc finger protein Cezanne |
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| Type: | Protein |
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| Mol. Mass.: | 92527.32 |
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| Organism: | Human |
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| Description: | Q6GQQ9 |
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| Residue: | 843 |
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| Sequence: | MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
HRF
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| BDBM443251 |
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| n/a |
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| Name | BDBM443251 |
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| Synonyms: | 7'-(1-Methyl-1H-indazol-5-yl)- 2'-oxo-1',4'-dihydro-2'H- spiro[pyrrolidine-3,3'- quinoline]-1-carbonitrile | US10654853, Example 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N5O |
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| Mol. Mass. | 357.4085 |
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| SMILES | Cn1ncc2cc(ccc12)-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1 |
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| Structure | 
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