Reaction Details |
| Report a problem with these data |
Target | Estrogen receptor [Y537S] |
---|
Ligand | BDBM443446 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Competition Binding Assay |
---|
Ki | 6.56±n/a nM |
---|
Citation | Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Selective estrogen receptor degraders US Patent US10654866 Publication Date 5/19/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Estrogen receptor [Y537S] |
---|
Name: | Estrogen receptor [Y537S] |
Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 66154.35 |
Organism: | Homo sapiens (Human) |
Description: | P03372[Y537S] |
Residue: | 595 |
Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
BDBM443446 |
---|
n/a |
---|
Name | BDBM443446 |
Synonyms: | US10654866, Example 5B | US11117902, Example 5A | US11634426, Example 5B |
Type | Small organic molecule |
Emp. Form. | C28H24F2N2O3 |
Mol. Mass. | 474.4986 |
SMILES | Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 |r| |
Structure |
|