Ki Summary

Reaction Details

Report a problem with these data

Target

Toll-like receptor 7

Ligand

BDBM450136

Substrate/Competitor

n/a

Meas. Tech.

Inhibition of the Activation Assay

IC50

13.0±n/a nM

Citation

Tojo, S; Isobe, Y; Ideue, E; Fujiwara, H; Urabe, D Substituted purine derivative US Patent US10703755 Publication Date 7/7/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM450136

n/a

Name

BDBM450136

Synonyms:

US10703755, Example 322

Type

Small organic molecule

Emp. Form.

C27H26FN7O2

Mol. Mass.

499.5394

SMILES

COc1nc(C)c2nc(-c3cncc(c3)C#N)n(Cc3ccc(OC4CN5CCC4CC5)cc3F)c2n1 |(-8.92,.3,;-7.74,-.69,;-6.41,.08,;-6.41,1.62,;-5.07,2.39,;-5.07,3.93,;-3.74,1.62,;-2.27,2.1,;-1.37,.85,;.17,.85,;.94,-.48,;2.48,-.48,;3.25,.85,;2.55,2.25,;.94,2.19,;3.34,3.57,;4.12,4.9,;-2.27,-.39,;-1.88,-1.88,;-.39,-2.28,;.7,-1.19,;2.19,-1.59,;2.59,-3.08,;4.07,-3.47,;5.16,-2.39,;4.76,-.9,;5.85,.19,;7.34,-.21,;7.74,-1.69,;6.65,-2.78,;6.65,-1.24,;5.85,-1.35,;1.5,-4.16,;.01,-3.77,;-1.08,-4.85,;-3.74,.08,;-5.07,-.69,)|

Structure