Reaction Details | |||
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Target | Activin receptor type-1 [172-499] | ||
Ligand | BDBM451773 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ADPGlo Assay | ||
IC50 | 7.00±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499] | |||
Name: | Activin receptor type-1 [172-499] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37139.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451773 | |||
n/a | |||
Name | BDBM451773 | ||
Synonyms: | US10710980, Example 5 | US10947218, Example 5 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H41N5O3 | ||
Mol. Mass. | 519.6782 | ||
SMILES | Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCCN1CCOCC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-6.62,4.32,;-5.28,3.55,;-3.95,4.32,;-2.61,3.55,;-2.61,2.01,;-3.95,1.24,;-5.28,2.01,;-6.62,1.24,;-7.95,2.01,;-6.62,-.3,;-7.95,-1.07,;-8.08,-2.6,;-9.48,-3.25,;-10.74,-2.37,;-11.94,-3.02,;-10.61,-.83,;-9.21,-.18,;-1.28,1.24,;-1.28,-.3,;.05,-1.07,;1.39,-.3,;1.39,1.24,;.05,2.01,;2.72,-1.07,;2.88,.47,;4.13,-.44,;5.16,-1.58,;4.39,-2.92,;5.01,-4.32,;6.55,-4.32,;7.32,-2.99,;8.86,-2.99,;9.63,-4.32,;11.17,-4.32,;11.94,-2.99,;11.17,-1.66,;9.63,-1.66,;2.88,-2.6,)| | ||
Structure |