Reaction Details | |||
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Target | Activin receptor type-1 [172-499] | ||
Ligand | BDBM451805 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ADPGlo Assay | ||
IC50 | 8.00±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499] | |||
Name: | Activin receptor type-1 [172-499] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37139.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451805 | |||
n/a | |||
Name | BDBM451805 | ||
Synonyms: | US10710980, Example 37 | US10947218, Example 37 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H32N4O2 | ||
Mol. Mass. | 444.5686 | ||
SMILES | CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(11.1,-4.32,;9.56,-4.32,;8.02,-4.32,;6.48,-4.32,;5.85,-2.92,;6.62,-1.58,;5.59,-.44,;4.35,.47,;4.19,-1.07,;4.35,-2.6,;2.85,-.3,;1.52,-1.07,;.18,-.3,;.18,1.24,;1.52,2.01,;2.85,1.24,;-1.15,2.01,;-1.15,3.55,;-2.48,4.32,;-3.82,3.55,;-5.15,4.32,;-3.82,2.01,;-2.48,1.24,;-5.15,1.24,;-6.48,2.01,;-5.15,-.3,;-6.64,-.69,;-7.04,-2.18,;-8.52,-2.58,;-9.61,-1.49,;-11.1,-1.89,;-9.21,-0,;-7.73,.39,)| | ||
Structure |