Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Activin receptor type-1 [172-499] | ||
Ligand | BDBM451819 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ADPGlo Assay | ||
IC50 | 8.00±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499] | |||
Name: | Activin receptor type-1 [172-499] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37139.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
| ||
BDBM451819 | |||
n/a | |||
Name | BDBM451819 | ||
Synonyms: | US10710980, Example 48 | US10947218, Example 48 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H31FN4O2 | ||
Mol. Mass. | 438.5376 | ||
SMILES | Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.31,4.95,;-2.98,4.18,;-1.64,4.95,;-.31,4.18,;-.31,2.64,;-1.64,1.87,;-2.98,2.64,;-4.31,1.87,;-5.64,2.64,;-4.31,.33,;-5.64,-.44,;-5.78,-1.97,;-7.17,-2.62,;-8.44,-1.74,;-9.66,-2.35,;-8.3,-.2,;-6.91,.45,;1.02,1.87,;1.02,.33,;2.36,-.44,;3.69,.33,;3.69,1.87,;2.36,2.64,;5.02,-.44,;5.19,1.1,;6.43,.19,;7.46,-.95,;6.69,-2.29,;7.46,-3.62,;8.89,-3.62,;9.66,-4.95,;5.19,-1.97,)| | ||
Structure |