| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 [172-499,R206H] |
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| Ligand | BDBM451789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caliper Assay |
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| IC50 | 10.00±n/a nM |
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| Citation |  Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 [172-499,R206H] |
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| Name: | Activin receptor type-1 [172-499,R206H] |
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| Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ALK2 FOP) (R206H aa 172-499) | Activin receptor type-1 (ALK2)(FOP)(R206H) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 37120.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 172-499 |
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| Residue: | 328 |
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| Sequence: | TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAHQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID
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| BDBM451789 |
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| n/a |
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| Name | BDBM451789 |
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| Synonyms: | US10710980, Example 21 | US10947218, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35FN4O3 |
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| Mol. Mass. | 494.6009 |
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| SMILES | Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| |
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| Structure | 
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